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As with all analgesic medications, the dosage should be adjusted to the intensity of the pain, the amount of analgesic taken previously, and the clinical response of each patient.
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The tablets should be swallowed whole without being broken, chewed or crushed.
The total daily dosage should be divided into two doses, usually equivalent, at 12-hour intervals.
Patients receiving strong opioids for the first time
Use the 10 mg dosage every 12 hours.
Patients previously treated with strong opioids
The initial dose should be determined according to the equivalent of the daily dose of morphine taken previously. By way of indication and in the absence of a clearly established equivalence, the ratio of equianalgesia is as follows: 10 mg oxycodone orally are equivalent to 20 mg of oral morphine. The dose of oxycodone will therefore be about half the dose of morphine administered previously.
Patients with mild to moderate hepatic impairment, renal insufficiency, elderly patients, weight loss patients
Administration of oxycodone should be safe. Start treatment at the lowest dose, 5 mg every 12 hours to minimize the incidence of adverse effects. The dose will then be adjusted individually according to the clinical condition of the patient.
Frequency of Evaluation
Do not dwell on a dosage that is ineffective. The patient should be seen closely until the pain is controlled. In practice, a daily assessment is recommended at the start of treatment.
If pain is not controlled, the dose should be increased by 25-50%, with a 12-hour interval between catches. In this dose adjustment process, there is no upper limit as long as the adverse effects are controlled.
Change in pharmaceutical form
In the case of a change from immediate release to a sustained-release form, the daily dosage will be unchanged.
Doses of oxycodone should be reduced gradually in order to avoid the emergence of a withdrawal syndrome.